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J., Anderson, L

92 Beyond the auditory system, convergent evidence from animal and human studies indicates that tinnitus is accompanied by structural and functional alterations in diverse brain regions, including the prefrontal, parietal, and cingulate cortices as well as the amygdala, hippocampus, nucleus accumbens, insula, thalamus, and cerebellum

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Published research protocols use administration frequencies ranging from daily to three-times-weekly depending on study objectives, with intermittent dosing often producing comparable or superior results to daily administration in long-term neuroplasticity studies

Epub 2007/12/07